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Prevalence and Associated Factors of Methicillin and Vancomycin Resistant Staphylococcus Aureus among Patients with Wound Infection at Hawassa University Comprehensive Specialized Hospital, Hawassa City, Sidama, Ethiopia

Author(s) : Biruktawit Sahle

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Issue Date : 2022-07-13T06:41:03Z
Abstract :
Background: The management of wound infections has turn out to be more difficult due to widespread bacterial resistance to antibiotics and due to an increasing occurrence of infections caused by methicillin resistant Staphylococcus aureus (MRSA). Vancomycin is the treatment of choice for MRSA. Even though vancomycin has been the most reliable therapeutic agent against infections caused by MRSA, there has been an alarming emergence of vancomycin resistant S. aureus (VRSA). Objective: To determine the prevalence and associated factors of methicillin and vancomycin resistant Staphylococcus aureus among patients with wound infection at Hawassa University Comprehensive Specialized Hospital from April to August 2021. Methodology: A hospital based cross-sectional study was conducted among admitted patients with wound infection at Hawassa University Comprehensive Specialized Hospital, from April to August, 2021. Wound swabs were collected aseptically and cultured for bacterial isolation and drug susceptibility testing. Structured questionnaire was used to collect socio-demographic data and other possible associated factors. The data was entered and analyzed using SPSS version 20. Descriptive statistics (Frequencies, percentage, median and interquartile range) were computed. Chi square test was used to assess the association of the dependent variable with the independent variables and P value < 0.05 was considered as statistically significant. Result: A total of 246 patients with wound infection were included in this study. S.aureus was isolated from 57 (23.2%) of the wound swabs of which 5(8.8%) were identified as MRSA. All the S.aureus strains were sensitive to linezolid. The highest resistance of S.aureus was for penicillin. All MRSA strains (5) were resistant to penicillin and all of them were sensitive to vancomycin and linezolid. Twenty six (45.6%) of S.aureus and all (100%) of the MRSA strains were multidrug resistant. Different factors were assessed for possible association with MRSA but all failed to show statistically significant association. Conclusion: The study showed low prevalence of S.aureus (23.2%) and MRSA (8.8%) in patients with wound infection at HUCSH. Both S.aureus and MRSA showed 100% sensitivity to linezolid and both showed high resistance to penicillin.
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