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Thesis

Virological Failure and Associated Risk Factors among adult Hiv- Patients an Highly Active Anti-Retroviral Therapy at Hawassa University Comprhensive Specialized Hospital; Sidama Regional State, Ethiopia.

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Issue Date : 2022-07-13T06:37:19Z
Abstract :
Background: Virological failure is key challenge that determined among people living with human immunodeficiency virus (HIV) been on highly active anti-retro viral therapy (HAART) and Viral load test is a monitoring test for prognosis of virological failure. However, there is shortage of study evidences across the country regarding burden and determinants of virological failure. Thus, this study assessed virological failure and associated risk factors. Objectives: To determine the magnitude of virological failure and associated risk factors among adult HIV patients on first line HAART at least for six months at HUCSH adult ART clinic from September, 2021 to January, 2022. Methods: A cross-sectional study was conducted among 418 PLWH who have been on HAART at least for six months. They were selected systematically. Socio-demographic and clinical variables were collected by structured questionnaire, and whole blood samples were collected to generate plasma for real time - polymerase chain reaction and viral level was quantified. Data was entered to SPSS 21 for analysis. A descriptive statistics used for frequency, proportion and summary measures were done for dependent and each independent variables. The binary and multiple logistic regression analysis were calculated for crude and adjusted odds ratio respectively to identify determinant variables of virological failure. Variables with P-value < 0.05 was considered as statistically significant. Result: From a total of 424 about 418 (98.6%) PLWH were involved in the study. Of these, 246 (58.9%) of them were female and 172 (41.1%) were male. The residents from rural were 36 (8.6%) and 382 (91.4) were living in urban areas. About 280 (67%) of PLWH were married and 56 (13.4%) were single. 256 (61.2 %) were orthodox religion, over all prevalence of HIV virological failure were 20 (4.8%), 95% CI, (2.73, 6.84%) and virologically failed clients have an association with base line CD4 T cells count below 500cells per ml (AOR= 3.536, 95% CI = 1.099, 11.375) and advanced WHO clinical stage (AOR= 3.701, 95% CI = 1.105, 12.390). Conclusion: The prevalence of virological failure was 20 (4.8 %). Low CD4 count, advanced WHO clinical stage and drug combination of three tabs used lonely were associated with virological failure. Designing effective mechanisms to maintain virological suppression is important.
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